First, it is the first time that we have proposed LINC01128/miR-25-3p/PTEN as a potential ceRNA regulatory axis to promote EGFR-TKI resistance via the PI3K/Akt pathway, which provides novel insights into the underlying molecular mechanisms of drug resistance to EGFR-TKIs in NSCLC. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.