Recently, Wang et al. found that two lncRNAs, ABTB1 and NPTN, exerted their functional roles via targeting the hsa-miR-150–5p/SERPINE1 axis, leading to drug resistance to EGFR-TKIs and an unfavorable survival rate in NSCLC (Wang T. et al., 2021). Here, EGFR is linked to non-small cell lung carcinoma.