Whilst correction of LDL-C concentrations for the cholesterol content of Lp(a) remains contentious, it is clear that in patients with very high Lp(a) concentrations, the cholesterol content of this lipoprotein particle may confound estimation of LDL-C and hence lead to a false positive clinical diagnosis of FH (Chan et al., 2019). This evidence concerns the gene LPA and familial hyperaldosteronism.