The mechanisms are unclear, but are likely mediated by oxidized phospholipids carried by Lp(a) (Yeang et al., 2016; Kamstrup et al., 2017), with contributions also from the cumulative burden of LDL-C, increasing age, and a history of hypertension (Mata et al., 2021; Pérez de Isla et al., 2021). Here, LPA is linked to hypertensive disorder.