The phenotypic diagnosis of FH may be confounded by the cholesterol content of Lp(a), particularly when this is extremely high and this should be accounted (Langsted et al., 2016; Chan et al., 2019); adjusting for the cholesterol content of Lp(a) is also important when phenotypically cascade testing relatives based on age, gender, and LDL-C levels. The gene discussed is LPA; the disease is familial hyperaldosteronism.