LPA and atherosclerosis: The two major risk equations, the SAFEHEART-RE (Pérez de Isla et al., 2017) and the FH-Risk-Score (Paquette et al., 2021), were derived from large prospective FH populations and included hyper-Lp(a) [Lp(a) > 50 mg/dL (Pérez de Isla et al., 2017) or ≥50 mg/dL (Paquette et al., 2021)] as a predictor of ASCVD risk in patients with the FH in primary (Pérez de Isla et al., 2017; Paquette et al., 2021) and secondary prevention settings (Pérez de Isla et al., 2017).