In these 135 positive/likely positive probands, which was caused by ADGRV1, CACNA1H, CHD8, GNAO1, HECW2, KCNQ2, KMT2A, KMT2C, MECP2, NAA15, SCN1A, SCN2A, SETBP1, SLC2A1, SMC1A, STXBP1, SYNGAP1 and TSC2 et al. are accompanied by the intellectual disability (Supplementary Table S1). The gene discussed is SYNGAP1; the disease is Intellectual disability.