Four genes, namely, MAPK8IP2, DDN, CACNA1E, and SH3GL2, were significant, with higher expression rates of 345.24 TPM, 7.93 TPM, 21.65 TPM, and 7.92 TPM, respectively, in the normal brain and were significantly lower in GBM with respective expression rates of 24.28 TPM, 1.313 TPM, 0.8 TPM, and 3.06 TPM. This evidence concerns the gene SH3GL2 and glioblastoma.