All the hub genes were validated by comparing their expression patterns in the GBM datasets of TCGA from which the genes PPP2R2C, DDN, SH3GL2, MAPK8IP2, CACNA1E, and BRSK1 were found significantly underexpressed, whereas SPARC, VIM, and MCM3 were highly expressed in both the TCGA datasets (including the TP53 mutant and non-mutant types) and GEO datasets. The gene discussed is SPARC; the disease is glioblastoma.