In addition, previous studies have found that NRP1 could affect the sensitivity of radiotherapy through NF-κB pathway in non-small cell lung cancer (Dong et al., 2015), so whether other pathways also involved in the process of circ-0007022/miR-338-3p/NRP1 axis’ regulation of radiotherapy resistance in ESCC still needs further research explore in the further. The gene discussed is NRP1; the disease is esophageal squamous cell carcinoma.