SMAD3 and cancer: Interestingly, about 42% of genes level were found significantly different in both cancer cell lines PANC1(upregulated 337/1629 and downregulated 343/1629) and BxPC3 (upregulated 363/1629 and downregulated 313/1629) compared with HPDE6C7, including TP53, SMAD3, PDGFA, etc. (Table S14, Supporting Information).