Therefore, we further analyzed 8359 pan‐cancer samples from TCGA database and found that MIR31HG expression under different MIR31HG mutation statuses in cancer tissues with deep deletion of the three genes (CDKN2A, CDKN2B, and MTAP) was significantly different from that in cancer tissues in which all MIR31HG and three genes were diploid. The gene discussed is CDKN2B; the disease is cancer.