Among them, cellular poly(C)-binding proteins (also called HnRNP E) [53] and CD151 [54] positively affect PRRSV infection, whereas retinoic acid-inducible gene I (RIG-I) and toll-like receptor 3 (TLR3) recognize PRRSV 3' UTR pseudoknot region and strongly induced type I interferons to curtail viral infection in PAMs [55]. Here, RIGI is linked to viral infectious disease.