Thus, the immune cells in the peripheral blood may reflect the composition, activity, and metabolic characteristics of those within the TME.25 26 Indeed, in the present study, when the composition of immune cells was examined by deconvoluting whole transcriptomic data of PBMCs with the CIBERSORT algorithm, CD8+ T cells that have prognostic relevance for tumor immunotherapy27 28 were significantly increased in the low-risk group according to the multivariate model. Here, CD8A is linked to neoplasm.