Expression of SIRT1 and SIRT6 is decreased in atherosclerotic plaques, while overexpression of SIRT1 or SIRT6 significantly attenuated oxidized LDL‐ or palmitate‐induced VSMC senescence and inhibited atherosclerosis (Gorenne et al., 2013; Grootaert et al., 2021). This evidence concerns the gene SIRT6 and atherosclerosis.