EGFR and its ligands (e.g., EGF, transforming growth factor-alpha) are overexpressed in up to 90% of head and neck cancer patients (17, 18, 19), are further induced by standard of care external beam radiation and DNA damaging agents (20, 21, 22), and are strongly linked to tumor progression (23, 24). Here, EGFR is linked to neoplasm.