Instead, cell cycle progression depends upon active recepteur d’origine nantais (RON) (also known as macrophage stimulating protein-1 receptor (MST1R) (28, 29, 30)) and the cytoplasmic kinase ABL1 (31), which, along with the Sdc4 homolog syndecan-2 (Sdc2) partners with Sdc4, EGFR, and the laminin-binding integrins specifically in the tumor cells. The gene discussed is SDC4; the disease is neoplasm.