It is becoming increasingly clear that hepatic glucose‐mobilizing effects of glucagon likely contribute to the hyperglycemia and related complications of diabetes (Foretz et al., 2005; Lee et al., 2012; Müller et al., 1973; Patil et al., 2020; Rix et al., 2019; Sharabi et al., 2019; Wewer Albrechtsen et al., 2019). The gene discussed is GCG; the disease is diabetes mellitus.