‘RALBP1‐associated Eps domain containing 2’, whose encoding gene REPS2’s expression levels are inversely correlated with those of TGIF1, blocks the proliferation and migration of tumor cells and inhibits their apoptosis, and is therefore an indicator of favorable prognosis as related to prostate, breast, and esophageal cancers.27, 28, 29. This evidence concerns the gene TGIF1 and esophageal cancer.