Five CVOTs, namely, LEADER3, SUSTAIN-6, REWIND, HARMONY, and AMPLITUDE-O [73] have consistently shown the safety and efficacy of GLP-1 agonists in patients with T2DM and have provided evidence of a secondary preventive effect of GLP-1 agonists in T2DM patients with CVD and kidney disease. Here, GLP1R is linked to kidney disorder.