SLC5A1 and type 2 diabetes mellitus: Sotagliflozin, the first dual SGLT1/2 inhibitor, approved for T1DM and T2DM in the EU and T2DM in the US, has exhibited CV benefits in patients with T2DM and chronic kidney disease [69]; a similar result was shown in patients with T2DM and HFrEF or HFpEF [70].