The genomic basis of ~ 80% of WHO Grade I meningiomas has been well described with somatic mutations affecting NF2, TRAF7, AKT1, KLF4, SMO, SUFU, POLR2A and PI3K pathway genes, along with copy number alterations, the latter of which are especially prevalent in higher grade tumors [3–7]. Here, TRAF7 is linked to meningioma.