In comparison to our 7-month-old mice, greater microglia activation has been reported in 12-month-old 3xTg-AD females compared to males [54], and more Iba1 + cells in the subiculum in 18-month-old 3xTg-AD females compared to males [55]; thus, sex differences may have emerged at later time points. The gene discussed is AIF1; the disease is Alzheimer disease.