ACE and infection: At the same time, however, immunosuppressive agents and ACE-inhibitors, often administered concurrently with the antineoplastic therapy, are proved to interact with the so-called cytokine and bradykinin storms, which are imputed to be at least partially responsible for severe infections, altering the clinical response to the virus and resulting in milder or absent symptoms compared to non-treated patients in particular sub-settings [15].