FUS and amyotrophic lateral sclerosis: For example, ALS patients have recently been administered investigational antisense oligonucleotides (ASOs) that bind to SOD1 RNA (Tofersen, NCT02623699), transcripts containing the G4C2 repeat expansions of the C9orf72 gene (BIIB078, NCT03626012), and patient-specific FUS mutations [4] (Jacifusen, NCT04768972).