Similar phenomena were also observed in a variety of polyQ diseases including SCA2 [15, 37], SCA6 [17, 38], and HD [12, 39, 40], etc. For example, in SCA2, the disease progression rates, as measured by Scale for the Assessment and Rating of Ataxia (SARA) and Neurological Examination Score for Spinocerebellar Ataxias (NESSCA), were also not uniform during the disease process: early phases of disease duration were related to slower progressions [15]. This evidence concerns the gene CACNA1A and spinocerebellar ataxia type 2.