TP53 and neoplasm: Univariate analysis of 14 factors (age > 50 years, tumor size > 1 cm, histology high grade, Ki-67 index > 30%, IHC basal-like marker positive, modified IHC subtype, PAM50 molecular subtypes, ROR, RS, istrong, high level TILs infiltration, P53 positivity, chemotherapy, and radiotherapy) showed that four factors significantly affected DFS: tumor size, PAM50 subtypes, RS, and ROR (Table 5, Fig. 6a).