Of note, given the low frequency of osteoporosis (N = 13, and only 1 had CA125 level ≥ 35 U/ml), osteoarthritis (N = 30, and only 3 had CA125 level ≥ 35 U/ml) and CAD (N = 10, but none had CA125 levels ≥ 35 U/ml) in the premenopausal subgroup, these variables were excluded from these analyses. This evidence concerns the gene MUC16 and coronary artery disorder.