Funston et al. have reported in a UK population-based study that 12.3% of those with CA125 level ≥ 35 U/ml were diagnosed with a non-ovarian cancer, and non-ovarian cancer diagnosis was found in 20.4% of women with CA125 level ≥ 35 U/ml who were ≥ 50 years of age [39].The results from our postmenopausal group deviated from such findings, perhaps reflecting some component of prior cancer-directed management and/or difference stemming from this study examining the US population. This evidence concerns the gene MUC16 and ovarian carcinoma.