For example, the expression of lncRNA retinoblastoma-associated transcript-1 (RBAT1) was significantly higher in both retinoblastoma (Rb) and bladder cancer (BCa) clinical tissues compared with normal tissues and RBAT promoted tumorigenesis by activating E2F3 transcription [19]. The gene discussed is E2F3-IT1; the disease is urinary bladder carcinoma.