TARDBP and amyotrophic lateral sclerosis: We previously reported that TDP-43 was elevated in both RNA and protein levels and that the expression of genes involved in sterol biosynthesis is decreased, in ALS MNs derived from induced pluripotent stem cells (iPSCs) generated from familial ALS patients with mutant TDP-4318, suggesting that TDP-43 may play a role in dyslipidemia in ALS.