Then, the proliferative, migrative and invasive capabilities of GBM cells were increased after hsa-miR-27a-3p mimic, but were distinctly suppressed after the addition of oe-EZH1, indicating that the overexpressed EZH1 offset the effects of overexpressed hsa-miR-27a-3p on the proliferation, migration and invasion of GBM cells (p < 0.05, n = 3) (Figs. S4E, F). This evidence concerns the gene EZH1 and glioblastoma.