CCN2 and glioblastoma: We observed that in GBM-EVs containing hsa-miR-27a-3p mimic and macrophages overexpressing CTGF, strengthened proliferation (1.5-fold, p < 0.05, n = 3), invasion (1.5-fold, p < 0.05, n = 3) and migration (1.6-fold, p < 0.05, n = 3) abilities was observed, which was abolished in GBM-EVs containing hsa-miR-27a-3p inhibitor and macrophages overexpressing CTGF (proliferation: 2.0-fold, p < 0.05, n = 3; migration: 2.0-fold, p < 0.05, n = 3; invasion: 2.2-fold, p < 0.05, n = 3) (Fig. 6L, M).