The plate clone and IC50 of the drug resistance experiment showed that the knockdown of LHPP increased the drug resistance of GC cells in vitro, whereas overexpression of LHPP caused a decrease in drug resistance of GC cells in vitro (Fig. 2E), which was verified in two cell lines (MGC-803 and MKN-28) (Supplementary Fig. 4). Here, LHPP is linked to gastric cancer.