In addition, HIF-1 cooperates with c-Myc to induce the expression of HK2 and PDK1, thereby further promoting the progress of aerobic glycolysis, enabling tumour cell protein synthesis, cell cycle progression and metabolic reprogramming, and finely regulating tumour cell growth and the metabolic adaptive response in a hypoxic environment [23–25]. This evidence concerns the gene HK2 and neoplasm.