Such proteasome and autophagy dysfunctions may exacerbate vulnerability not only in neurons but also in astrocytes, making these glial cells less effective in clearing pathological aggregates and in supporting neuronal homeostasis; as shown in the context of ALS FIG4 mutations (Ferguson et al, 2009) and in a lysosomal storage disease study (Di Malta et al, 2012). This evidence concerns the gene FIG4 and lysosomal storage disease.