ACY1 has been described in OMIM as a gene causing aminoacylase 1 deficiency (ACY1D), a rare inborn error of metabolism characterized by increased urinary excretion of specific N-acetyl amino acids, and most affected individuals show neurologic abnormalities such as intellectual disability, seizures, hypotonia, and motor delay.36 Here, ACY1 is linked to Neurological conditions associated with aminoacylase 1 deficiency.