A polygenic score for T2D was significantly associated with increased likelihood of T2D diagnosis in both p.C282Y homozygous male participants (OR, 1.86: 95% CI, 1.55–2.24; p = 2 × 10−11) and female participants (OR, 1.72: 95% CI, 1.39–2.12; p = 6 × 10−7), though in both cases, the association did not significantly differ from that seen in HFE wild‐type genotype participants (interaction p > 0.05). Here, HFE is linked to type 2 diabetes mellitus.