We also created a polygenic score for TF saturation using 19 genetic variants, and results were highly similar to the iron polygenic score results reported above (Figure 1; Table S4); however, polygenic scores for ferritin and TIBC were not associated with diagnosis of hemochromatosis or any comorbidities (p > 0.05; Figure 1; Table S4). The gene discussed is TF; the disease is hemochromatosis type 1.