To examine the effects of SUMOylation on truncated tau in more detail, a series of fusion proteins were generated based on full-length (Fl-Tau) 4-repeat (4R) and the truncated PSP-associated tau (Tr-Tau) fragment lacking 160 amino acids from the N-terminal domain (truncated tau construct contains residues 161–441). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.