Immunohistochemistry for phosphorylated tau (P-Tau) (Fig. 1A), SUMO1 (Fig. 1B) and SUMO2 (Fig. 1C) in the basal ganglia did not exhibit any characteristic staining except faint glial cytoplasmic immunoreactivity in control brain, on the other hand, PSP brain showed perinuclear accumulations of P-Tau in neurons consistent with globose type neurofibrillary tangles commonly observed in PSP (Fig. 1D) [35]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.