ERBB2 and ductal breast carcinoma in situ: Among the four meta-analyses, a significant positive association was consistently reported between overall risk of recurrence and pre-menopausal status, young age, African-American race, symptomatic versus screen detected DCIS, presence of positive surgical margins, high grade, multifocality, presence of comedo necrosis, HER2 positivity and a family history of breast cancer [66–69].