Amplification and overexpression of oncogenes such as Cyclin E (CCNE1) [87, 88, 89], Ras [90], Myc [91, 92] and CDC25A [88] have also been linked with increased replication stress and enhanced sensitivity to ATRi, whereas genetic screens have identified a range of additional cancer‐associated ATRi‐related synthetic lethal effects including those with ARID1A [93], RNASEH2A/RNASEH2B [94], POLE3/POLE4 [95], APOBEC3A/APOBEC3B [96] amongst others [97, 98, 99, 100, 101, 102, 103, 104, 105]. This evidence concerns the gene MYC and cancer.