They cleverly realised that they could use fluorescence‐activated cell sorting (FACS) to enrich neuronal nuclei that either contained TDP‐43 or did not and then perform RNA sequencing to compare the transcriptomes between TDP‐43+ and TDP‐43‐ neuronal nuclei from brains of FTD/ALS patients. Here, TARDBP is linked to amyotrophic lateral sclerosis.