We first constructed an Ang II infusion mouse model, consistent with our previous report,7 mice with Ang II infusion exhibited podocyte injury and renal dysfunction, as evidenced by a marked increase in glomerulosclerosis and mesangial matrix expansion (Figure 1A), exacerbated foot processes fusion (Figure 1A), and a significant ACR (Figure 1B) compared with the control group. The gene discussed is AGT; the disease is glomerulosclerosis.