Notably, comparison of the tau interactome in I2448 M mutant cells with a human AD brain‐derived tau interactome (Drummond et al., 2020) revealed 43 overlapping proteins including MAP4, PIN1, MAPT, and STXBP1, providing further evidence for an association of the I2558 M mutation with AD pathology (Figure S6). This evidence concerns the gene MAPT and Alzheimer disease.