Among these, 25 genes (AIM2, CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, GPX4, GSDMB, GSDMC, GSDMD, GSDME, IL1B, NLRC4, NLRP2, NLRP3, NLRP6, NLRP7, NOD1, NOD2, PJVK, PLCG1, PYCARD, SCAF11, and TNF) were highly expressed in HNSCC tissue and only ELANE showed higher expression in normal tissues (Figure 2A). Here, GPX4 is linked to head and neck squamous cell carcinoma.