Among these, 25 genes (AIM2, CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, GPX4, GSDMB, GSDMC, GSDMD, GSDME, IL1B, NLRC4, NLRP2, NLRP3, NLRP6, NLRP7, NOD1, NOD2, PJVK, PLCG1, PYCARD, SCAF11, and TNF) were highly expressed in HNSCC tissue and only ELANE showed higher expression in normal tissues (Figure 2A). The gene discussed is TNF; the disease is head and neck squamous cell carcinoma.