Among these, 25 genes (AIM2, CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, GPX4, GSDMB, GSDMC, GSDMD, GSDME, IL1B, NLRC4, NLRP2, NLRP3, NLRP6, NLRP7, NOD1, NOD2, PJVK, PLCG1, PYCARD, SCAF11, and TNF) were highly expressed in HNSCC tissue and only ELANE showed higher expression in normal tissues (Figure 2A). This evidence concerns the gene CASP5 and head and neck squamous cell carcinoma.