PI3 and brain ischemia: Along the same lines, flavonoids have also shown the ability to inhibit platelet aggregation induced by various agonists [55,56,57,58], protect against cerebral ischemia and reperfusion injury in rats, enhances cerebrovascular angiogenesis in human umbilical vein endothelial cells [59], inhibit PI3 production [60,61], increases cAMP levels [56] and inhibits levels of inflammatory markers [62].