MOG and optic neuritis: ROC curve analysis revealed that a plasma LCN2 level of 36.32 ng/mL measured using ELISA could predict optic neuritis recurrence with a sensitivity and specificity of 62.5% and 81.8%, respectively, and a MOG-IgG titer of 3.5 measured using cell-based assays could predict optic neuritis recurrence with a sensitivity and specificity of 44.4% and 90.9%, respectively.