This, in peripheral nerve terminals, induces the release of vesicles containing neuropeptides, including calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal peptide (VIP), which play several roles in the context of tissue damage and are known to induce or sensitize peripheral pain, especially in musculoskeletal disorders. The gene discussed is VIP; the disease is musculoskeletal system disorder.