PKD1 and autosomal dominant polycystic kidney disease: ADPKD is a monogenic disorder, with a penetrance of 100% and an incidence of 1:1000 individuals, caused by the mutation of two different genes located on the primary cilia genes of renal tubules: polycystin 1 (PKD1) and polycystin 2 (PKD2) [2,3,4,5].