The following features at diagnosis were evaluated as risk factors for cumulative incidence of AML evolution and OS in patients with isolated del20q: age (<75 years vs. ≥75 years), gender, Hb (<10 g/dL vs. ≥10 g/dL), PLT (<100 × 109/L vs. ≥100 × 109/L), WBC (<2.5 × 109/L vs. ≥2.5 × 109/L), marrow blasts (<5% vs. ≥5%), IPSS (low vs. intermediate-1), and transfusion need (no vs. yes). Here, GSTM1 is linked to acute myeloid leukemia.