Levels of circulating CD3+CD4+ and CD3+CD8+ T cells did not differ between patients with and without previous acute GVHD (Table 5): the same was true for Th2 and Th17 cells, whereas a significantly higher proportion of circulating Th1 cells was observed in patients without previous acute GVHD. The gene discussed is CD8A; the disease is acute graft versus host disease.