The study by Schelbert et al. also detected that higher ECV was a strong predictor in univariate analysis (HR: 1.93/5% ECV; 95% CI: 1.50–2,50; p < 0.001), as well as an independent predictor in multivariate analysis (HRadjusted:1.52/5% ECV; 95% CI: 1.05–2.21; p = 0.03), for hospitalization with HF or death from cardiovascular causes in patients with HFpEF or at risk of developing HFpEF (based on elevated levels of brain natriuretic peptide) [11]. The gene discussed is NPPB; the disease is hydrops fetalis.