Immunomodulatory drugs (ImiDs, including thalidomide and its analogs) promote cancer cells apoptosis, foster the proliferation and activity of NK and T cells (through cereblon-dependent degradation of the transcription factors IKZF1 and IKZF3) [80,81], improve the production of INF-γ and IL-2 by Th1 cells, enhance ADCC [38], and contain CD4+ and CD8+ IL-10 release, which enhances NK cell activation [82]. The gene discussed is CD8A; the disease is cancer.