CD38 and Miyoshi myopathy: For treatment of refractory MM patient, these agents can be combined with mAb directed to specific targets: daratumumab, as well as isatuximab, by targeting CD38 on the MM cells surface, either in monotherapy or in combination with bortezomib and/or dexamethasone, is capable of promoting ADCC, apoptosis, complement-mediated cytotoxicity, antibody-dependent cellular phagocytosis (ADCP) and T cells response, targeting CD38 on the MM cells surface.