PVR and Paraproteinemia: When triggered by its stress-induced ligands (Nectin2/CD112 and PVR/CD155), which are frequently over-expressed on malignant PC surfaces, the DNAM-1 receptor controls T and NK cell activation [29] and confers resistance to bortezomib and cyclophosphamide, contributing to slowed paraproteinemia and enhanced survival in mice models [28].