During the active phase of MM disease, the involvement of BMME in “cancer immunoediting” becomes more evident: specifically, MSCs upregulate IL-6 production and exhibit high levels of CD40/CD40L and adhesion molecules, such as VCAM-1, ICAM-1, LFA-3, junctional adhesion molecule-A (JAM-A), and human leukocyte antigen (HLA) system molecules (HLA-DR and HLA-ABC) [38]. Here, IL6 is linked to cancer.