TLR4 and open-angle glaucoma: The most common POAG genes studied in Asian populations include populations include MYOC, OPTN, CYP1B1, CAV1-CAV2, TGFBR3, ATOH7, CDKN2B/CDKN2B-AS1, SIX6, MMP, LOXL-1, TP53, TNF, APOE, TLR4, NFT4, WDR36, IL-1, and VAV2-VAV3, but numerous other loci have been noted (Table 2).