The first patient was a 59-year-old never-smoking female diagnosed with lung adenocarcinoma harboring an EGFR L858R substitution on exon 21 (verified by polymerase chain reaction [PCR] in the tumor specimen) with bilateral lung metastases, liver metastases, and a left-sided malignant pleural effusion. This evidence concerns the gene EGFR and lung adenocarcinoma.