This pathoanatomic condition mimics acquired and potentially life-threatening thrombophilia such as the antiphospholipid syndrome, in which patients develop pathogenic autoantibodies targeting phospholipids and phospholipid-binding proteins (aPL antibodies) such as prothrombin and beta 2 glycoprotein I (beta 2GPI). Here, APOH is linked to Rare hereditary thrombophilia.