In terms of the importance of the PWR in this study, the role of thrombocytopenia in patients with CLD has several mechanisms, such as a reduction in hepatic thrombopoietin production, splenomegaly due to increased splenic vein pressure, immune-mediated destruction, and destruction resulting from an inflammatory response with tumor necrosis factor [22,23]. This evidence concerns the gene TNF and congenital secretory chloride diarrhea 1.