ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Consistent with these animal studies, MH individuals who are OW or with obesity had higher levels of adiponectin than metabolically unhealthy individuals who are OW or with obesity (6478.5 vs. 4941.9 and 5592.9 vs. 4712.1 ng/mL, in metabolically healthy vs. unhealthy OW and metabolically healthy vs. unhealthy obesity respectively; p < 0.001, data not shown).