In the study, they defined the MH with six metabolic markers including BP, C-reactive protein (CRP), triacylglycerols, LDL-cholesterol, HDL-cholesterol and HbA1c [33], while the new definition of MH was derived from the systemic assessment of CVD mortality data and various anthropometric and metabolic factors among individuals with obesity [16]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.