VTN and cancer: Despite that, PAI-1 is an inhibitor of u-PA in the plasminogen activator system, and theoretically, PAI-1 should be anticipated to have an anti-tumorigenic function; surprisingly, PAI-1 mediates in adhesion, migration, invasion, proliferation and apoptosis of normal and malignant cells through its anti-protease and vitronectin-binding functions and cancer cell apoptosis inhibition as well [30,32].