In summary, (1) family disease, such as family heart disease, hypertension, asthma, stroke, immune system diseases, and allergies; (2) patients’ background, BMI, gender, education level, best corrective visual acuity (BCVA), spherical equivalent; or (3) patients themselves suffered from hypertension, diabetes, hyperlipidemia, and chronic pain; drug use for blood pressure, antihistamines, anxiety, stress, or even the detection of CRP index in the blood are helpful to detect EOC, which is a topic worthy of discussion. Here, CRP is linked to allergic disease.