The ATTRwt staging system used a higher NT-proBNP cut-off value >3000 pg/mL, compared to the cut-off point > 1800 pg/mL used in AL amyloidosis, and a cut-off value of ≥ 0.05 ng/mL for hsTnT [121]. The gene discussed is NPPB; the disease is AL amyloidosis.