However, data about systemic inflammation biomarkers in ATTR-CA are scarce, compared to the well-defined status in risk stratification of cardiovascular events in HF for biomarkers such as soluble suppression of tumorigenicity 2 (sST2), IFN, TNF, GDF15, pentraxin-3, and lipocalin-2/NGAL [13,135,136]. This evidence concerns the gene LCN2 and hydrops fetalis.